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Antinuclear Antibody: Diffuse Pattern
The diffuse pattern of nuclear fluorescence may be found in sera of patients with systemic lupus erythematosus, whether they are acutely ill or not. It can be demonstrated in sera from other patients such as those with rheumatoid arthritis, chronic discoid lupus, and in a small percentage of normal elderly individuals. High titers are most common in patients with systemic lupus erythematosus. The diffuse pattern is caused by antibody to nucleoprotein (DNA-histone complex) and can mask a speckled or peripheral pattern.
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Title:
Antinuclear Antibody: Diffuse Pattern
Description:
The diffuse pattern of nuclear fluorescence may be found in sera of patients with systemic lupus erythematosus, whether they are acutely ill or not. It can be demonstrated in sera from other patients such as those with rheumatoid arthritis, chronic discoid lupus, and in a small percentage of normal elderly individuals. High titers are most common in patients with systemic lupus erythematosus. The diffuse pattern is caused by antibody to nucleoprotein (DNA-histone complex) and can mask a speckled or peripheral pattern.
Reference Number:
99-03-0018
Disease:
Systemic Lupus Erythematosus
Image Type:
Photomicrograph
Color Mode:
Color
File Name:
99-03-0018.jpg
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